Limestone is 2-4 in its inaugural year of playing football. Paine College is 0-6.
With Limestone nursing a 26-18 lead early in the fourth quarter, quarterback Jonathan Clark found Fleming in one-on-one coverage down the right sideline for the longest offensive play of the season. Fleming made the catch, shook his defender with one move, and was off to the end zone to give the Saints a 33-18 cushion with 12:28 remaining in regulation.
Fleming had 96 yards.
The Saints scored three defensive touchdowns including a 101-yard interception return by Titus Williams (Greenwood).
Joshua Simmons (Moncks Corner.) had an interception return of 55 yards for a touchdown and Rod Oglesby (Gaffney.) returned a fumble for a two-yard TD.
There was a 1:18 weather delay during halftime.
Limestone hits the road for its first game outside the state traveling to face Fort Valley State University next Saturday at 2 p.m.